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More commonly, thrombocytopenia is induced by the drugs used to treat RA, including methotrexate and other disease-modifying antirheumatic drugs DMARDs.

The drugs are myelosuppressive, meaning they suppress the bone marrow's ability to produce blood cells, including red blood cells, white blood cells, and platelets.

Any abnormal rise or fall in the platelet cell count can cause noticeable symptoms in some people.

In other cases, the person may not experience any symptoms at all and will only learn of the abnormal levels if blood tests are performed for other reasons.

Mild to moderate thrombocytosis is common with rheumatoid arthritis. Symptoms are usually mild to non-existent. It is rare for RA-associated thrombocytosis to cause severe complications.

The one exception may be in older adults with cardiovascular disease in whom chronic thrombocytopenia may increase the risk of a stroke or heart attack.

Note, however, that long-term RA in and of itself increases cardiovascular risk. In people with RA, thrombocytopenia may be mild and cause few signs or symptoms.

If the platelet count drops beneath a certain threshold, the inability to clot will manifest with increasingly obvious symptoms. In rare cases, the platelets may be so low that internal bleeding occurs.

Common signs and symptoms of thrombocytopenia include:. Platelet disorders are primarily diagnosed with a complete blood count CBC.

This is a blood test that assesses the overall composition of your blood as well as its individual components, including your platelets.

While the CBC can provide definitive evidence of a platelet abnormality, your doctor may also perform blood tests known as erythrocyte sedimentation rate ESR and C-reactive protein CRP to measure the level of generalized inflammation in your body.

Your doctor may explore other possible causes if your symptoms are unusual or severe. Depending on the suspected cause, the investigation may include a bone marrow biopsy , imaging tests, blood tests, or a blood culture.

The differential diagnoses for thrombocytosis may include:. The differential diagnoses for thrombocytopenia may include:.

The treatment of platelet disorders in people with rheumatoid arthritis can vary depending on the underlying cause. Thrombocytosis in people with RA typically requires no treatment and will usually improve once the underlying inflammation is controlled.

The medication options include those that directly reduce inflammation and others that temper the autoimmune response. Effort should also be made to quit smoking , exercise regularly , and lose excess weight , all of which can reduce inflammation and keep your RA symptoms under control.

Immune thrombocytopenia also tends to improve once the autoimmune response is brought under control. Corticosteroids like prednisone may be used to support therapy by directly reducing inflammation.

NSAIDs may also be prescribed but are generally avoided in people with low platelet counts due to increased risk of bleeding. If your platelet count doesn't recover with treatment or is especially severe, your doctor may recommend intravenous immunoglobulin IVIG.

Immunoglobulin is another type of antibody that your body normally makes to fight off infections. With IVIG, immunoglobulin purified from the blood of healthy donors is delivered through an IV drip, usually for several hours a day for one to five days.

The advantage of IVIG is that it can raise your platelet count quickly, albeit temporarily. If your RA medications are causing a drop in your platelet count, your doctor may recommend a reduction in your dose.

The drugs most commonly associated with this are:. If the symptoms are especially severe or platelet levels fail to recover with a dose reduction, your doctor may stop treatment and switch you to another drug.

One of the more effective alternatives is the biologic drug Rituxan rituximab , which tempers the immune response by targeting B-cells , the very cells that destroy platelets in the autoimmune assault.

Dealing with chronic inflammation? An anti-inflammatory diet can help. Our free recipe guide shows you the best foods to fight inflammation. Get yours today!

Cleveland Clinic. Updated October 25, National Organization for Rare Disorders. Immune thrombocytopenia. Updated May 30, Thrombocythemia and thrombocytosis.

Factors associated with myelosuppression related to low-dose methotrexate therapy for inflammatory rheumatic diseases. PLoS One. Food and Drug Administration.

What it tests : This test measures the level of RF, which acts as an antibody against gamma globulins in the blood. However, doctors cannot conclude this from an RF test alone as several other conditions can increase the amount of RF in the body, including gout.

Similarly, a negative RF test result is insufficient evidence to confirm that a person does not have RA.

What it tests : Uric acid is a waste product that tends to be present in high amounts when a person has gout, which is another form of inflammatory arthritis.

Interpreting results : The presence of high levels of uric acid indicate that a person is more likely to have gout than RA.

The correct diagnosis is vital to managing RA. Early treatment can help slow down the progression of the disease. Before having a blood test, it is best to check with a doctor if it is necessary to prepare for it in any way, such as by not eating for several hours beforehand.

Psoriatic arthritis PsA is a type of arthritis more likely to affect people with psoriasis. Common triggers for a flare include stress, smoking, and….

Rheumatoid arthritis or RA, can affect the ankle joints in the same way as other joints, causing pain, inflammation, and swelling. RA in the ankles is….

Rheumatoid arthritis RA is a chronic condition. Many factors affect the prognosis of people with RA, including age, lifestyle factors, and disease….

Blood tests for rheumatoid arthritis: What to know. Medically reviewed by Debra Sullivan, Ph. Blood tests for rheumatoid arthritis Additional tests Outlook Rheumatoid arthritis is an autoimmune disorder that causes inflammation in the joints.

Blood tests for rheumatoid arthritis. Share on Pinterest Various blood tests can help diagnose rheumatoid arthritis. Share on Pinterest A doctor can explain the results of a blood test.

Additional tests. Twelve early signs of rheumatoid arthritis.

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